The potential protective effects of malacca (Phyllanthus emblica L.) extract against doxorubicin-induced cardiotoxicity in male Wistar rats

Doxorubicin as a chemotherapy agent is most widely used in cancer treatment. Long-term use at predetermined dose has side effect, namely cardiotoxicity. Doxorubicin-induced cardiotoxicity considered to be caused by reactive oxygen species (ROS), which also characterized increasing CK-MB enzyme levels the blood. To reduce impact of doxorubin-induced toxicity, study was conducted on natural antioxidant sources with cardioprotective capabilities vivo. Phyllanthus emblica L. fruit sample for source antioxidants extracted using ethanol. Then performed phytochemical screening secondary metabolites contained it. This extract administered orally various doses experimental animal Wistar rats and induced doxorubicin these animals. The were measured, heart organ histopathology test performed. results this indicate that P. contains alkaloids, tannins, flavonoids, terpenoids, phenolics, triterpenoids compounds. Extract treatment 400 mg/kg BW showed best reduction great improvements regular arrangement shape myocardial muscle cells cardiac tissue. remarkably decreasing tissue doxorubicin-induced potential protective effect against